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Potent St. John's Wort standardized extract (0.3% hypericin) Supports mood and aids in the relief of depression2-month supply per bottleSt. John's Wort is an old herbal remedy and common plant native to many parts of the world, particularly North America and Europe. This herb has positive affects on the brain's biochemistry and works in the relief of depression. Studies have shown that it can be as effective as synthetic antidepressants, but has far fewer and milder side effects.One of the main active ingredients in St. John's Wort is hypericin. Hypericin is believed to interfere with or inhibit the enzyme called monoamine oxidase (MAO). MAO's role in the human body is to break down substances such as serotonin and norepinephrine. Hypericin, along with other components in St. John's Wort, inhibits MAO, allowing levels of serotonin and norepinephrine in the brain to increase. Increased levels of these neurotransmitters elevate mood, create a feeling of serenity and alleviate depression. In this way, St. John's Wort acts an an alternative to the synthetic antidepressants.St. John's Wort is widely used in Europe where medical journals have published over 23 successful double-blind controlled clinical studies in the control of depression. More than 80% of doctors in Germany prescribe St. John's Wort for their patients on a regular basis. There are no side effects from long-term usage.